LED-NMR + RPKA

LED-NMR is a data-rich analytical tool that is suitable for modern RPKA techniques. In studing an enantioselective photocatalytic reaction, Wes and Steven found that LED-NMR RPKA enabled determination of rate laws in a fraction of …

Cooperative Photocatalytic Stereocontrol

In the process of developing an enantioselective [2+2] photocycloaddition of vinylpyridines, Steven and Wes discovered stereochemical cooperativity between a chiral Brønsted acid catalyst and a chiral Ir photocatalyst. It’s a gratifying demonstration that matched/mismatched effects …

Cu-mediated Decarboxylative Coupling

The Yoon lab’s first publication of 2022 is a new oxidative decarboxylative coupling process based on the intrinsic photochemistry of Cu(II) carboxylate complexes. Check out the paper in Nature Chemistry. Congratulations Yukki, Sam, Grace, Kimberly, …

Brønsted Acid Catalyzed Chromophore Activation

Evan, Matt, and Bohyun investigated a novel strategy for highly enantioselective organocatalytic photochemistry in which no individual reaction component absorbs light. Very pleased to announce the publication of this collaborative project with the Baik group …

Asymmetric γ-alkyoxycarbonyl synthesis

Xiao and Yukki’s study of asymmetric Giese additions involving α-silylethers involves an in-depth mechanistic analysis of holistic photocatalyst considerations for successful photocatalytic reactions. Check out the paper in OL!

Oxidative Alkene Functionalizations

Nic and Grace have developed a protocol for intramolecular oxidative functionalization of sterically bulky alkenes with diverse heteronucleophiles as a way to show that photoredox catalysis can address long-standing limitations of transition metal catalyzed processes. …