Truxinate Org Syn Prep

Our star undergraduate Rodrigo wondered if a commercial chiral Brønsted acid could be used in our asymmetric photochemistry instead of the optimal BINOL-derived triflimide we originally used. The answer is yes! Rodrigo reports the enantioselective …

Understanding photocatalytic aziridination

Alana, Mihai, and Arindam formed an unstoppable collaboration team through the SuPRCat CCI with the Paton and Damrauer groups to understand a new, remarkably general method for photocatalytic alkene aziridination. A combination of preparative, computational, …

Predicting Ir emissions using AI

We had a great collaboration with the Schmidt group on an AI model for predicting the emission spectra of Ir complexes. Based on a big data set collected and published by the Bernhard group. Now …

Asymmetric Paternò–Büchi Reaction

Jesse, Tahoe, Wes, and Yerin have a terrific new paper in JACS today about the long road to an asymmetric catalytic Paternò–Büchi reaction. A great collaboration with Kent and the Wright lab at UW.

Solid-state synthesis of the truxillates

In JACS today, Ellie, Hyung Joo, and Matt report a general approach to the truillate family of natural products enabled by solid state photochemistry. Synthetically, this paper complements the route to the truxinates we published …

Enantioselective 6π Photoelectrocyclizations

The latest chapter in our ongoing collaboration with the Baik group is now published in JACS. Wes and Hanna lead a comprehensive synthetic, spectroscopic, and computational study of highly enantioselective 6π photoelectrocyclizations. Previously on the …

Cu oxidant review

A coda to Grace’s successful PhD career: her review describing the use of Cu(II) salts as terminal oxidants in photochemical reactions is online at OBMC.

General synthesis of the truxinates

Part of the motivation for continued development of enantioselective photocatalysis has been the possibility of streamlining the synthesis of densely substituted small-ring compounds. Matt, Matthew, and Herman have devised a demonstration of this principle by …

Allylic amination

Grace, Ellie, and Nic have leveraged an unexpected observation into an unusual method for allylic amination using Cu(II)-mediated radical–polar crossover.  Online now at OL!