The latest chapter in our ongoing collaboration with the Baik group is now published in JACS. Wes and Hanna lead a comprehensive synthetic, spectroscopic, and computational study of highly enantioselective 6π photoelectrocyclizations. Previously on the …
papers
Cu oxidant review
A coda to Grace’s successful PhD career: her review describing the use of Cu(II) salts as terminal oxidants in photochemical reactions is online at OBMC.
General synthesis of the truxinates
Part of the motivation for continued development of enantioselective photocatalysis has been the possibility of streamlining the synthesis of densely substituted small-ring compounds. Matt, Matthew, and Herman have devised a demonstration of this principle by …
Allylic amination
Grace, Ellie, and Nic have leveraged an unexpected observation into an unusual method for allylic amination using Cu(II)-mediated radical–polar crossover. Online now at OL!
Photosensitized De Mayo reactions
Riley, Andrew, and Eunji’s study showing how Lewis acids can improve the scope of sensitized De Mayo reactions is online at Org Lett!
Fe-mediated decarboxylative coupling
Grace and Sam’s magnum opus on Fe(III)-mediated photochemical couplings of carboxylic acid feedstocks is published in Chem. This is the second installment in a productive collaboration with Scott Bagley and Mark Bundesmann at Pfizer.
TA spectroscopy for photocatalytic synthesis
TA spectroscopy can provide detailed insight into the mechanisms of photocatalytic reactions. Read Wes’ tutorial review in this year’s Specialist Periodical Reports – Photochemistry.
Cross-ketonization
Andrew developed a method to selectively combine two different carboxylic acid feedstocks into unsymmetrical ketones using a metallaphotoredox strategy. The result is a modern take on the industrial process of acid ketonization, updated for complex …
Uncontrolled Sensitization in Asymmetric Photocatalysis
Steven worked with Zeb Girvin (Miller group), Laura Cotter and Hyung Yoon (Mayer group) in a fun three-lab collaborative project on asymmetric [2+2] photocycloadditions of acyclic vinylpyiridines, now up at JACS. The reaction involves an …
LED-NMR + RPKA
LED-NMR is a data-rich analytical tool that is suitable for modern RPKA techniques. In studing an enantioselective photocatalytic reaction, Wes and Steven found that LED-NMR RPKA enabled determination of rate laws in a fraction of …