Solid-state synthesis of the truxillates

In JACS today, Ellie, Hyung Joo, and Matt report a general approach to the truillate family of natural products enabled by solid state photochemistry. Synthetically, this paper complements the route to the truxinates we published …

Enantioselective 6π Photoelectrocyclizations

The latest chapter in our ongoing collaboration with the Baik group is now published in JACS. Wes and Hanna lead a comprehensive synthetic, spectroscopic, and computational study of highly enantioselective 6π photoelectrocyclizations. Previously on the …

Cu oxidant review

A coda to Grace’s successful PhD career: her review describing the use of Cu(II) salts as terminal oxidants in photochemical reactions is online at OBMC.

General synthesis of the truxinates

Part of the motivation for continued development of enantioselective photocatalysis has been the possibility of streamlining the synthesis of densely substituted small-ring compounds. Matt, Matthew, and Herman have devised a demonstration of this principle by …

Allylic amination

Grace, Ellie, and Nic have leveraged an unexpected observation into an unusual method for allylic amination using Cu(II)-mediated radical–polar crossover.  Online now at OL!

Fe-mediated decarboxylative coupling

Grace and Sam’s magnum opus on Fe(III)-mediated photochemical couplings of carboxylic acid feedstocks is published in Chem. This is the second installment in a productive collaboration with Scott Bagley and Mark Bundesmann at Pfizer.

Cross-ketonization

Andrew developed a method to selectively combine two different carboxylic acid feedstocks into unsymmetrical ketones using a metallaphotoredox strategy. The result is a modern take on the industrial process of acid ketonization, updated for complex …