Research interests in the Yoon laboratory include: Organic synthesis, Asymmetric Catalysis, Photochemistry, Reaction mechanisms, and Organometallics

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One major theme of research in the Yoon laboratory is the use of photochemistry to assemble otherwise unaccessible structures with precise stereocontrol

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Yoon Group News

  • Cross-ketonization

    Andrew developed a method to selectively combine two different carboxylic acid feedstocks into unsymmetrical ketones using a metallaphotoredox strategy. The result is a modern take on the industrial process of acid ketonization, updated for complex …

  • Uncontrolled Sensitization in Asymmetric Photocatalysis

    Steven worked with Zeb Girvin (Miller group), Laura Cotter and Hyung Yoon (Mayer group) in a fun three-lab collaborative project on asymmetric [2+2] photocycloadditions of acyclic vinylpyiridines, now up at JACS. The reaction involves an …

  • LED-NMR + RPKA

    LED-NMR is a data-rich analytical tool that is suitable for modern RPKA techniques. In studing an enantioselective photocatalytic reaction, Wes and Steven found that LED-NMR RPKA enabled determination of rate laws in a fraction of …

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Research

The Yoon Research Group is a collaborative team of researchers in synthetic organic chemistry. We specialize in organic photochemistry, radical chemistry, and stereoselective synthesis. We are particularly interested in the development of novel catalytic methodology as a strategy for increasing process efficiency, controlling reaction selectivity, and reducing the environmental impact of chemical synthesis.

Photocatalysis

A central theme of research in the Yoon lab is the development of synthetically useful photochemical reactions that can be conducted using visible light. Most organic compounds, however, absorb light only at short UV wavelengths that are relatively poorly emitted in the solar spectrum. We are investigating strategies to use transition metal photosensitizers that can catalyze interesting new photochemical reactions at long wavelengths of visible light that are abundant in the solar spectrum.

Oxidation Chemistry

A common research interest across our research projects involves the investigation of novel oxidation reactions. In one area, we have investigated the chemistry of oxaziridines, which are three-membered heterocycles that undergo a wide range of unusual oxidative functionalization reactions. We are also identifying the reaction parameters that are most important for successful oxidative photochemical reactions.