How do you functionalize a C–C bond? Cade, Caitlin, Matthieu, and Felix have a compelling method for migrating an oxygen atom into an unstrained C(sp3)–C(sp3) bond. In cyclic contexts, this enables the editing of a saturated carbocycle into a ring-expanded heterocycle. In acyclic contexts, it enables the permutation of the heavy atoms in a hydroxymethyl functional group. First posted on ChemRxiv, now open access in Nature Synthesis.
